Melanopsin ganglion cells, critical players in visual system development
نویسندگان
چکیده
منابع مشابه
Cephalochordate Melanopsin: Evolutionary Linkage between Invertebrate Visual Cells and Vertebrate Photosensitive Retinal Ganglion Cells
Animal photoreceptor cells can be classified into two distinct types, depending on whether the photopigment is borne on the membrane of a modified cilium (ciliary type) or apical microvilli (rhabdomeric type) [1]. Ciliary photoreceptors are well known as vertebrate rods and cones and are also found in several invertebrates. The rhabdomeric photoreceptor, in contrast, is a predominant type of in...
متن کاملThe development of melanopsin-containing retinal ganglion cells in mice with early retinal degeneration.
In mammals, the neuronal pathways by which rod and cone photoreceptors mediate vision have been well documented. The roles that classical photoreceptors play in photoentrainment, however, have been less clear. In mammals, intrinsically photosensitive retinal ganglion cells (ipRGCs) that express the photopigment melanopsin project directly to the suprachiasmatic nucleus of the hypothalamus, the ...
متن کاملIntrinsic and extrinsic light responses in melanopsin-expressing ganglion cells during mouse development.
Melanopsin (Opn4) is a photopigment found in a subset of retinal ganglion cells (RGCs) that project to various brain areas. These neurons are intrinsically photosensitive (ipRGCs) and are implicated in nonimage-forming responses to environmental light such as the pupillary light reflex and circadian entrainment. Recent evidence indicates that ipRGCs respond to light at birth, but questions rema...
متن کاملMultiple photoreceptors contribute to nonimage-forming visual functions predominantly through melanopsin-containing retinal ganglion cells.
In the absence of functional rod and cone photoreceptors, mammals retain the ability to detect light for a variety of physiological functions such as circadian photoentrainment and pupillary light reflex. This is attributed to a third class of photoreceptors, the intrinsically photosensitive retinal ganglion cells that express the photopigment melanopsin. Even though in the absence of rods and ...
متن کاملMelanopsin Ganglion Cells: A Different Way of Seeing Things
The major features and functioning of the mammalian visual system are well known. For many years, the consensus has been that incoming light is detected by two specialized cell types—rods and cones— which reside in the retina, the tissue that lines the back of the eye. These cells contain specialized photopigments—proteins that set off a cellular signaling cascade when they are struck by photon...
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ژورنال
عنوان ژورنال: Journal of Vision
سال: 2019
ISSN: 1534-7362
DOI: 10.1167/19.15.16